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Int J Biol Sci ; 11 How to cite this article: However, no studies have investigated any causality between androgen, androgen receptor AR expression, and adenosine monophosphate activated protein kinase AMPK activation in the endometrium under physiological and pathological conditions. In addition to its negative effects on endocrine activity and metabolism, PCOS has adverse impacts on female reproduction [ 1 , 3 ]. For example, women with PCOS generally have chronic anovulation, and their endometria tend to remain in a proliferative state due to the lack of counterbalance by progesterone [ 4 ].
It is generally believed that the failure of reproductive success in PCOS patients could be in part due to endometrial dysfunction [ 7 , 8 ].
Copyright remains with the author s or their institution s. Permission for reuse free in most cases can be obtained from RightsLink. Published on the web 13 April Canadian Journal of Earth Sciences, , 53 9: One porphyry intrusion yielded a U—Pb age of Mineralization occurs in three stages:
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Received Aug 1; Accepted Jan This article has been cited by other articles in PMC. Abstract At the crossroads between Africa and Eurasia, Arabia is necessarily a melting pot, its peoples enriched by successive gene flow over the generations. Estimating the timing and impact of these multiple migrations are important steps in reconstructing the key demographic events in the human history. An mtDNA-based founder analysis, corroborated by detailed analysis of the whole-mtDNA genome, affords an alternative means by which to identify, date and quantify multiple migration events at greater time depths, across the full range of modern human history, albeit for the maternal line of descent only.
In Arabia, this approach enables us to infer several major pulses of dispersal between the Near East and Arabia, most likely via the Gulf corridor. Introduction The issue of admixture in human populations is normally addressed by genome-wide GW studies, and several approaches have been developed to date admixture events [ 1 , 2 , 3 , 4 , 5 ].
Admixed populations bear chromosomes with segments of DNA from all contributing source groups, the size of which decreases over successive generations until recombination renders them undetectably short. Several algorithms attempt to date admixture events by inferring the size of the nuclear ancestry segments, and these can work well when dating recent episodes in human history, such as the sub-Saharan African input into the New World [ 6 ], but they fail to detect several known episodes that took place at earlier times, such as the African input into Iberia [ 1 ] and genetic exchanges across the Red Sea [ 7 ].
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History[ edit ] One of the challenges in studying abiogenesis is that the system of reproduction and metabolism utilized by all extant life involves three distinct types of interdependent macromolecules DNA , RNA , and protein. This suggests that life could not have arisen in its current form, which has led researchers to hypothesize mechanisms whereby the current system might have arisen from a simpler precursor system.
He proposed that these nucleotide cofactors represent “fossils of nucleic acid enzymes”. Opinions differ, however, as to whether RNA constituted the first autonomous self-replicating system or was a derivative of a still-earlier system. On the other hand, the discovery in that activated pyrimidine ribonucleotides can be synthesized under plausible prebiotic conditions  suggests that it is premature to dismiss the RNA-first scenarios. Ribozymes play vital roles, such as that of the ribosome , an RNA-protein complex responsible for protein synthesis.
Many other ribozyme functions exist; for example, the hammerhead ribozyme performs self-cleavage  and an RNA polymerase ribozyme can synthesize a short RNA strand from a primed RNA template.
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